6-AMINO-9 BETA-D-ARABINOFURANOSYLFLUOROPURINE
Fludarabine
CAS: 21679-14-1
Molecular Formula: C10H12FN5O4
6-AMINO-9 BETA-D-ARABINOFURANOSYLFLUOROPURINE - Names and Identifiers
| Name | Fludarabine |
| Synonyms | f-ara-a NSC 118218 Fludarabine NSC 118218H Fludarabine base Fludarabine(base) 2-Fluoroadeninearabinoside 9-beta-D-Arabinofuranosyl-2-fluoroadenine 9-bata-D-Arabinofuranosyl-2-fluoroadenine 9-beta-d-arabinofuranosyl-2-fluoro-adenin 2-Fluoroadenine-9-bata-D-arabinofuranoside 6-AMINO-9 BETA-D-ARABINOFURANOSYLFLUOROPURINE 9--D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine 9-beta-d-arabinofuranosyl-2-fluoro-9h-purin-6-amin 9-(beta-D-arabinofuranosyl)-2-fluoro-9H-purin-6-amine |
| CAS | 21679-14-1 |
| EINECS | 244-525-5 |
| InChI | InChI=1/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6+,9-/m1/s1 |
6-AMINO-9 BETA-D-ARABINOFURANOSYLFLUOROPURINE - Physico-chemical Properties
| Molecular Formula | C10H12FN5O4 |
| Molar Mass | 285.23 |
| Density | 2.17±0.1 g/cm3(Predicted) |
| Melting Point | 265-268°C |
| Boling Point | 747.3±70.0 °C(Predicted) |
| Specific Rotation(α) | D25 +17 ±2.5° (c = 0.1 in ethanol) |
| Flash Point | 405.8°C |
| Water Solubility | Soluble in DMF, DMSO, methanol or ethanol. Sparingly soluble in water |
| Solubility | Soluble in (<1 mg/mL,25°C), DMSO (57 mg/mL,25°C), and ethanol (<1 mg/mL,25°C). |
| Vapor Presure | 1.86E-23mmHg at 25°C |
| Appearance | White or white-like crystalline powder |
| Color | White to Pale Yellow |
| Merck | 13,4152 |
| BRN | 1225932 |
| pKa | 13.05±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Refractive Index | 1.876 |
| MDL | MFCD00132942 |
| Physical and Chemical Properties | Crystallization from ethanol-water, melting point 260 °c. [Α] D23 17 ° ± 2.5 °(C = 0.1, ethanol). UV absorption maximum (Ph 1, pH 7, ph 13):262,261,262nm(ε 13200,14800,15000). Difficult to dissolve in water and organic solvents. Fiudarabine 5 '-monophosphorate: C10Hl3FN5O7P. [75607-67-9]. Soluble in water. |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| Target | STAT1(Vascular smooth muscle cells) |
6-AMINO-9 BETA-D-ARABINOFURANOSYLFLUOROPURINE - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R39/23/24/25 - R39 - Danger of very serious irreversible effects R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | AU6207000 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29349990 |
6-AMINO-9 BETA-D-ARABINOFURANOSYLFLUOROPURINE - Reference
| Reference Show more | 1. Zou Zhijian, Sun Hongli, Shen Yunfeng, et al. Study on the Effect of miR-214 Mediated Chronic Lymphocytic Leukemia on Fludarabine Resistance [J]. Chinese Journal of Experimental Hematology 2019 027(005):1395-1401. |
6-AMINO-9 BETA-D-ARABINOFURANOSYLFLUOROPURINE - Introduction
Fludarabine is a STAT1 activation inhibitor in vascular smooth muscle cells, which specifically reduces STAT1 protein level (and mRNA level), but has no such effect on other STATs. It is also an inhibitor of DNA synthesis. Fludarabine is metabolized into an active ingredient in the body, which can inhibit ribonucleotide reductase, DNA polymerases, DNA primers, and DNA ligases, thereby inhibiting DNA synthesis. This product has a selective toxic effect on lymphocytes.
Last Update：2022-10-16 17:14:57
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Product Name: Fludarabine(Fludarabine Phosphate EP Impurity E) Visit Supplier Webpage Request for quotationCAS: 21679-14-1
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Fludarabine Visit Supplier Webpage Request for quotationCAS: 21679-14-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Multiple Specifications
Product Name: Fludarabine Request for quotationCAS: 21679-14-1
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302
Product List: View Catalog
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